Twist Bioscience Corp (NASDAQ: TWST) has seen notable insider activity in recent weeks. On November 21, 2025, insider Cho Dennis sold 757 shares for $20,063, at an average price of $26.50 per share. Following this transaction, Cho Dennis retains 145,402 shares, valued at approximately $4.52 million.
Other insiders were also active. Finn Patrick John, President and COO, sold 1,776 shares for $47,070, leaving him with 332,883 shares. Green Paula, SVP of Human Resources, sold 598 shares for $15,849 and now holds 167,789 shares, worth roughly $5.22 million. These transactions reflect a moderate reduction in holdings by senior management while maintaining significant stakes.
Analyst Coverage and Ratings
Several analysts have updated their outlooks for TWST. Stephens initiated coverage on November 4, 2025, with an Overweight rating and a price target of $41. Wolfe Research began coverage in mid-December with an Outperform rating, while Guggenheim recommended Buy on June 4, 2024. Goldman Sachs upgraded its rating from Neutral to Buy on January 17, 2024.
Additionally, Berenberg started covering the stock on September 27, 2023, recommending a Buy rating with a $27 price target, signaling growing institutional interest in TWST.
Price Performance Overview
On Tuesday, TWST stock surged 6.07%, closing at $31.11. Over the past five days, the stock has climbed 19.65%, showing strong short-term momentum. Despite this, TWST has declined 25.32% year-to-date and 33.05% over the past year.
The stock’s 52-week high of $55.33 was reached on January 24, 2025, while the 52-week low of $23.30 was recorded on November 14, 2025, highlighting the stock’s recent volatility within the biotechnology sector.
Support and Resistance Levels
Technical analysis points to support at $29.50, with a secondary support level at $27.89. On the upside, resistance is found at $32.10, with further resistance near $33.09, providing potential targets for traders and investors monitoring short-term price movements.
Short Interest Trends
Short interest in TWST increased slightly as of November 14, 2025, rising by 38,200 shares to a total of 10.9 million shares. In comparison, the prior-month short interest on October 15, 2025, was 10.86 million shares, marking a 0.35% increase. This modest rise in short interest suggests that market sentiment is cautiously optimistic, with limited downward pressure from short sellers.
